Concepedia

Publication | Open Access

The Oncogenic FOXL2 C134W Mutation Is a Key Driver of Granulosa Cell Tumors

DOIFull Paper Access

22

Citations

29

References

2022

Year

Elena Llano, Anne‐Laure Todeschini, Natalia Felipe‐Medina, María D. Corte‐Torres, Yazmine B. Condezo, Manuel Sánchez‐Martín, Sara López-Tamargo, Aurora Astudillo, Xosé S. Puente, Alberto M. Pendás,
Cancer Research

Abstract

A newly generated mouse model carrying a FOXL2 mutation characteristic of adult-type granulosa cell tumors shows that FOXL2 C134W shifts the transcriptome towards a signature of granulosa cell cancer and drives tumorigenesis.

References

YearCitations

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