Modulation of the Crosstalk between Schwann Cells and Macrophages for Nerve Regeneration: A Therapeutic Strategy Based on a Multifunctional Tetrahedral Framework Nucleic Acids System (Adv. Mater. 46/2022)

Abstract

Axon Regeneration In article number 2202513, Sirong Shi, Yungfeng Lin, and co-workers report a multifunctional tetrahedral-framework nucleic acids system, denoted as MiDs. The peripheral nervous system is like a vibrant rainforest. As flexible in conformation as cats, the powerful MiDs enhance the role of macrophages (represented by the fireflies) and Schwann cells (butterflies) on damaged peripheral nerves, allowing them to grow freely like newborn vines.