Activation of <scp>eIF4E</scp>‐binding‐protein‐1 rescues <scp>mTORC1</scp>‐induced sarcopenia by expanding lysosomal degradation capacity

Abstract

We identify 4EBP1 as a communication hub coordinating protein synthesis and degradation to protect proteostasis, revealing therapeutic potential for activating lysosomal degradation to mitigate sarcopenia.