Concepedia

Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect

Wenkai Chen, Wenping Lin, Naichun Yu, Linlin Zhang, Zuoxing Wu, Yongjie Chen, Zongguang Li, Fengqing Gong, Na Li, Xu He,

International Journal of Nanomedicine · 2022 · 20 citations · 24 references

DOIFull text

Open access

Abstract

The potent Drp1 agonist, rifampicin, induced OS apoptosis and exosome loading, improving OS targeting and mouse survival rates. EXO-RIF is a promising strategy for the treatment of diverse malignancies.

References

24

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

Sushrut Kamerkar, Valerie S. LeBleu, Hikaru Sugimoto et al. · Nature · 2017 · 2.5K citations

, , +6

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

Myoung Soo Kim, Matthew J. Haney, Yuling Zhao et al. · Nanomedicine Nanotechnology Biology and Medicine · 2015 · 1.4K citations · Full text

, , +9

New Horizons in the Treatment of Osteosarcoma

New England Journal of Medicine · 2021 · 597 citations

Pancreatic cancer-targeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironment

Wenxi Zhou, Yu Zhou, Xinli Chen et al. · Biomaterials · 2020 · 430 citations

, , +8

Rifampicin: A New Orally Active Rifamycin

N. Maggi, C.R. Pasqualucci, R Ballotta et al. · Chemotherapy · 1966 · 266 citations

, , +17