Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect - Concepedia

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Activation of Dynamin-Related Protein 1 and Induction of Mitochondrial Apoptosis by Exosome-Rifampicin Nanoparticles Exerts Anti-Osteosarcoma Effect

DOI Full Paper Access

20

Citations

24

References

2022

Year

Wenkai Chen, Wenping Lin, Naichun Yu, Linlin Zhang, Zuoxing Wu, Yongjie Chen, Zongguang Li, Fengqing Gong, Na Li, Xu He,

International Journal of Nanomedicine

Abstract

The potent Drp1 agonist, rifampicin, induced OS apoptosis and exosome loading, improving OS targeting and mouse survival rates. EXO-RIF is a promising strategy for the treatment of diverse malignancies.

References

	Year	Citations
Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer Sushrut Kamerkar, Valerie S. LeBleu, Hikaru Sugimoto, Nature Oncogenic KrasPancreatic CancerExosomesMedicineExtracellular Microvesicles	2017	2.5K
Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells Myoung Soo Kim, Matthew J. Haney, Yuling Zhao, Nanomedicine Nanotechnology Biology and Medicine Drug TargetingOncologyPolymer-drug ConjugateMedicineTumor Targeting	2015	1.4K
New Horizons in the Treatment of Osteosarcoma New England Journal of Medicine	2021	597
Pancreatic cancer-targeting exosomes for enhancing immunotherapy and reprogramming tumor microenvironment Wenxi Zhou, Yu Zhou, Xinli Chen, Biomaterials Pancreatic CancerExosomesImmunologyExtracellular MicrovesiclesTumor Targeting	2020	430
Rifampicin: A New Orally Active Rifamycin N. Maggi, C.R. Pasqualucci, R Ballotta, Chemotherapy Pharmaceutical SciencePharmacotherapyAntimicrobial ChemotherapyPre-clinical PharmacologyDrug Resistance	1966	266
Macrophage-tumor chimeric exosomes accumulate in lymph node and tumor to activate the immune response and the tumor microenvironment Shuang Wang, Feng Li, Tong Ye, Science Translational Medicine ImmunologyBiological MicroenvironmentsImmunoeditingExtracellular MicrovesiclesImmunotherapeutics	2021	221
Designer exosomes for targeted and efficient ferroptosis induction in cancer via chemo-photodynamic therapy Jianbing Du, Zhuo Wan, Cong Wang, Theranostics	2021	219
Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial Guy Thwaites, Matthew Scarborough, Alexander J. Szubert, The Lancet	2017	183
Bone marrow mesenchymal stem cell-derived exosomal miR-206 inhibits osteosarcoma progression by targeting TRA2B Hongliang Zhang, Jun Wang, Tingting Ren, Cancer Letters MedicineStem CellsPathologyMesenchymal Stem CellStem Cell Trafficking	2020	138
Optimised Electroporation for Loading of Extracellular Vesicles with Doxorubicin Angus J. Lennaárd, Doste R. Mamand, Rim Jawad Wiklander, Pharmaceutics NanoparticlesNanomedicineExtracellular VesiclesCell-based Drug DeliveryNaked Doxorubicin	2021	127

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