PML Body Component Sp100A Is a Cytosolic Responder to IFN and Activator of Antiviral ISGs

Hongchang Dong, Wencheng Wu, Jingjing Li, Yilei Ma, Xiaomei Deng, Deyin Guo, Pei Xu

mBio · 2022 · 13 citations · 56 references

DOIFull text

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Concepts

Abstract

PML bodies sit at the center stage of various important biological processes; however, the signal transduction networks of these macromolecular protein complexes remain enigmatic. The present study illustrates, in detail and for the first time, the course of signal receiving, processing, and implementation by PML bodies in response to IFN and virus infection.

References

56