Concepedia

IP3R activity increases propensity of RyR-mediated sparks by elevating dyadic [Ca2＋]

Joshua Chung, Agnė Tilūnaitė, David Ladd, Hilary Hunt, Christian Soeller, Edmund J. Crampin, Stuart T. Johnston, H. Llewelyn Roderick, Vijay Rajagopal

Mathematical Biosciences · 2022 · 13 citations · 37 references

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37

Calcium Sparks: Elementary Events Underlying Excitation-Contraction Coupling in Heart Muscle

Heping Cheng, W. Jonathan Lederer, Mark B. Cannell · Science · 1993 · 1.9K citations

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Ca2+ signalling between single L-type Ca2+ channels and ryanodine receptors in heart cells

Shi‐Qiang Wang, Long‐Sheng Song, Edward G. Lakatta et al. · Nature · 2001 · 409 citations

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Optical single-channel resolution imaging of the ryanodine receptor distribution in rat cardiac myocytes

David Baddeley, Izzy Jayasinghe, Leo Lam et al. · Proceedings of the National Academy of Sciences · 2009 · 311 citations · Full text

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Functional InsP3 receptors that may modulate excitation–contraction coupling in the heart

Peter Lipp, Mika Laine, Stephen C. Tovey et al. · Current Biology · 2000 · 245 citations · Full text

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A Simple Numerical Model of Calcium Spark Formation and Detection in Cardiac Myocytes

Gregory D. Smith, Joel Keizer, Michael D. Stern et al. · Biophysical Journal · 1998 · 210 citations · Full text

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