Alveolar epithelial cells and microenvironmental stiffness synergistically drive fibroblast activation in three-dimensional hydrogel lung models

Thomas Caracena, Rachel Blomberg, Rukshika S. Hewawasam, Zoe E. Fry, David W. H. Riches, Chelsea M. Magin

Biomaterials Science · 2022 · 30 citations · 52 references

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Concepts

Abstract

Increased microenvironmental stiffness and alveolar epithelial cells were both required to drive fibroblast activation in biomaterial-based 3D models of pulmonary fibrosis.

References

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