Luminescence · 2022 · 11 citations · 59 references
EngineeringOncologic ImagingBiomedical EngineeringIntracellular PhPh ChangesMolecular ImagingBiophysicsNovel Imaging MethodLarge Stokes ShiftFluorescence ImagingCell BiologySingle-molecule DetectionEmission Fluorescent ProbePka ValueBioelectronicsBiomedical ImagingCell Ph ChangesChemical ProbeMedicineCell ImagingPhosphorescence
The detection of intracellular pH is crucial for elucidating the pathological process of cancers, as well as for medical diagnostic applications. Here, we developed an aggregation-induced emission active pH-responsive fluorescent probe (TPE-DCP) for sensitively detecting cell pH changes. The probe shows obvious pH-sensing properties at ~615 nm, with a pKa value of 6.82 and a good linear pH response ranging from 8.5 to 4.5. TPE-DCP holds advantages such as excellent anti-interference performance, good photostability, and low cytotoxicity, and has been successfully used to image intracellular pH changes in cells.
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