Heterogeneity of Ventilation/Perfusion Mismatch at Different Levels of PEEP and in Respiratory Mechanics Phenotypes of COVID-19 ARDS

Abstract

In subjects with COVID-related ARDS placed on invasive mechanical ventilation for > 48 h, PEEP had a heterogeneous effect on V̇/Q̇ mismatch and, on average, higher levels were not able to reduce shunt. The subject's compliance could influence the effect of PEEP on V̇/Q̇ mismatch since an increased shunt was observed in subjects with lower compliance, whereas the opposite occurred in those with higher compliance.