[68Ga]Ga-DOTA-FAPI-04 PET/MR in patients with acute myocardial infarction: potential role of predicting left ventricular remodeling

Abstract

Abstract Purpose To assess predictive value of 68 Ga-labeled fibroblast activation protein inhibitor-04 ([ 68 Ga]Ga-DOTA-FAPI-04) PET/MR for late left ventricular (LV) remodeling in patients with ST-segment elevated myocardial infarction (STEMI). Methods Twenty-six patients with STEMI were included in the study. [ 68 Ga]Ga-DOTA-FAPI-04 PET/MR was performed at baseline and at average 12 months after STEMI. LV remodeling was defined as >10% increase in LV end-systolic volume (LVESV) from baseline to 12 months. Results The LV remodeling group demonstrated higher [ 68 Ga]Ga-DOTA-FAPI-04 uptake volume (UV) at baseline than the non-LV remodeling group ( p < 0.001). [ 68 Ga]Ga-DOTA-FAPI-04 UV at baseline was a significant predictor (OR = 1.048, p = 0.011) for LV remodeling at 12 months after STEMI. Compared to clinical information, MR imaging and cardiac function parameters at baseline, [ 68 Ga]Ga-DOTA-FAPI-04 UV demonstrated better predictive ability (AUC = 0.938, p < 0.001) for late LV remodeling, with sensitivity of 100.0% and specificity of 81.3%. Conclusions [ 68 Ga]Ga-DOTA-FAPI-04 PET/MR is an effective tool to non-invasively quantify myocardial fibroblasts activation, and baseline [ 68 Ga]Ga-DOTA-FAPI-04 UV may have potential predictive value for late LV remodeling.