Concepedia

Biological evaluation, docking studies, and <i>in silico</i> ADME prediction of some pyrimidine and pyridine derivatives as potential EGFR <sup>WT</sup> and EGFR <sup>T790M</sup> inhibitors

Tarfah Al‐Warhi, Ahmed A. Al‐Karmalawy, Ayman Abo Elmaaty, Maha A. Alshubramy, Marwa Abdel‐Motaal, Taghreed A. Majrashi, Medhat Asem, Ahmed Nabil, Wagdy M. Eldehna, Marwa Sharaky

Journal of Enzyme Inhibition and Medicinal Chemistry · 2022 · 48 citations · 71 references

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Abstract

were assessed for their EGFR kinase (Wild and T790M) inhibitory activities, revealing eligible potential. Additionally, molecular docking, ADME, and SAR studies were carried out for the investigated candidates.

References

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