Knockdown and mutation of Pou4f3 gene mutation promotes pyroptosis of cochleae in cisplatin-induced deafness mice by NLRP3/caspase-3/GSDME pathway

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

Xing Liu, Zhibin Zhang, Jianbin Ruan et al. · Nature · 2016 · 3.2K citations · Full text

Life Sciences, Cell Biology, Immunology +9

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Yupeng Wang, Wenqing Gao, Xuyan Shi et al. · Nature · 2017 · 3.2K citations

Life Sciences, Cell Biology, Oncology +13

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

Corey Rogers, Dan A. Erkes, Alexandria Nardone et al. · Nature Communications · 2019 · 831 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Mutation in Transcription Factor <i>POU4F3</i> Associated with Inherited Progressive Hearing Loss in Humans

Oz Vahava, Robert J. Morell, Eric D. Lynch et al. · Science · 1998 · 350 citations

Life Sciences, Genetics, Molecular Genetics +17

Essential role of POU–domain factor Brn-3c in auditory and vestibular hair cell development

Mengqing Xiang, Lin Gan, Daqing Li et al. · Proceedings of the National Academy of Sciences · 1997 · 338 citations

Life Sciences, Genetics, Neuroscience +17