Anti-Epileptic Drug Target Perturbation and Intracranial Aneurysm Risk: Mendelian Randomization and Colocalization Study

Abstract

<i>CNNM2</i> is a driver of the pleiotropy between IA and anti-epileptic drug targets. Administration of the anti-epileptic drugs phenytoin, valproic acid, or carbamazepine may be expected to decrease <i>CNNM2</i> levels and therefore subsequently decrease IA risk. <i>CNNM2</i> is therefore an important target to investigate further for its role in the pathogenesis of IA.