Iron–Organic Framework Nanoparticle-Supported Tungstosilicic Acid as a Catalyst for the Biginelli Reaction

Abstract

In this work, a metal–organic framework with an octahedral morphology supported by a tungstosilicic acid (TSA) nanocatalyst has been successfully synthesized through a postsynthetic modification approach and referred to as TSA/MIL-88B. The as-prepared catalyst was efficiently obtained from Biginelli reactions among benzaldehyde, urea, and 1,3-dicarbonyl compound. Depending on the synergistic effect of exposed metal iron sites and the supported Brønsted acid sites, the hybrid materials exhibited high catalytic activity. Additionally, the environmentally friendly nanocatalyst could be recycled seven times with a little reduction in the catalytic performance. This study also provides a way for the application of such porous organic polymer functionalization in organic synthesis.