Anti-Inflammatory Effects of Coumarin–Selenophene Derivatives on LPS-Stimulated RAW 264.7 Macrophage Cells

Abstract

Coumarin and coumarin derivatives have been known for their anti-viral, anti-oxidant, anti-cancer and anti-inflammatory activities. Changes in biological activity when these biologically active compounds are combined with different heterocyclic groups are among the topics of interest to researchers in recent years. Therefore, a series of coumarin–selenophene hybrid compounds have been synthesized. Products are fully characterized by NMR and FT-IR spectroscopic techniques. The prepared compounds are screened for their anti-inflammatory potencies on LPS induced mouse macrophage cell line (RAW 264.7). The results showed that coumarin–selenophene hybrid compounds were not cytotoxic at the tested concentrations on RAW 264.7 macrophages. Also, these compounds decreased TNF- α, IL-6 secretion, and NO, PGE2 production in dose-depended manner. According to our results, coumarin–selenophene hybrid compounds have the capacity to moderate the immune response and a potential anti-inflammatory activity.