Melatonin decreases plasma <scp>TNF</scp>‐α and improves nonenzymatic antioxidant defence and insulin sensitivity in rats with apical periodontitis fed a high‐fat diet

Abstract

Apical periodontitis and HFD promoted IR, and the association of AP with diet promoted IR exacerbation; this resistance might have been caused by an increase in TNF-α. AP promoted more intense changes in lipid oxidative damage than in protein oxidative damage. In non-enzymatic antioxidant defence, it was observed that both AP and HFD and their association promoted a decrease in GSH levels. Overall, ME treatment reversed changes such as oxidative stress and IR.