Gut-Kidney Impairment Process of Adenine Combined with Folium sennae-Induced Diarrhea: Association with Interactions between Lactobacillus intestinalis, Bacteroides acidifaciens and Acetic Acid, Inflammation, and Kidney Function

Abstract

Adenine combined with <i>Folium sennae</i>-induced diarrhea, altered the structure and function of the gut content microbiota in mice, causing the enrichment of the characteristic bacteria <i>Lactobacillus intestinalis</i> and <i>Bacteroides acidifaciens</i>. The interactions between <i>Lactobacillus intestinalis</i>, <i>Bacteroides acidifaciens</i> and acetic acid, intestinal inflammation, and kidney function might be involved in the process of gut-kidney impairment in adenine, combined with <i>Folium sennae</i>-induced diarrhea.