Multifunctional Au Modified Ti₃C₂-MXene for Photothermal/Enzyme Dynamic/Immune Synergistic Therapy

Abstract

Ti₃C₂-MXene-based composites provide multifunctional interfaces in diagnosis and treatment of tumors. Herein, we proposed a multifunctional nanoplatform based on Ti₃C₂-MXene-Au nanocomposites, which combines photothermal properties and peroxidase-like activity, accomplishing synergistic photothermal therapy (PTT) and enzyme dynamic therapy (EDT) accompanied by photoacoustic (PA) and thermal dual-mode imaging <i>in vivo</i>. Furthermore, PTT induces immunogenic cell death, and EDT promotes cell apoptosis, facilitating dendritic cell (DC) maturation and T cell infiltration into the tumor. On this basis, the antibody OX40 (αOX40) was utilized to further contribute immune therapy for reversing the immunosuppressive tumor microenvironment by activating CD4⁺ and CD8⁺ T cells. In summary, a triune of PTT/EDT/antitumor immune therapy is achieved by combining Ti₃C₂-MXene-Au nanocomposites and αOX40, which possesses several strong features of good biocompatibility, NIR-controlled targeting, significant cancer cell killing, and satisfactory biosafety <i>in vitro</i> and <i>in vivo</i>. Our work might highlight the promising application of MXene-based nanoplatforms for cancer therapy.