Co-opted genes of algal origin protect C. elegans against cyanogenic toxins

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Michael I. Love, Wolfgang Huber, Simon Anders · Genome biology · 2014 · 100.5K citations · Full text

Life Sciences, Bioinformatics, Biostatistics +15

Basic local alignment search tool

Stephen F. Altschul, Warren Gish, Webb Miller et al. · Journal of Molecular Biology · 1990 · 94.5K citations

Life Sciences, Bioinformatics, Sequence Analysis +3

IQ-TREE: A Fast and Effective Stochastic Algorithm for Estimating Maximum-Likelihood Phylogenies

Lam-Tung Nguyen, Heiko A. Schmidt, Arndt von Haeseler et al. · Molecular Biology and Evolution · 2014 · 27.5K citations · Full text

Life Sciences, Bioinformatics, Biology +15

HISAT: a fast spliced aligner with low memory requirements

Daehwan Kim, Ben Langmead, Steven L. Salzberg · Nature Methods · 2015 · 26.1K citations · Full text

Engineering, Computer Engineering, Computer Science +3

ModelFinder: fast model selection for accurate phylogenetic estimates

Subha Kalyaanamoorthy, Bùi Quang Minh, Thomas K. F. Wong et al. · Nature Methods · 2017 · 18.8K citations

Life Sciences, Bioinformatics, Evolutionary Biology +13