Sphingosine-1-Phosphate Improves Outcome of No-Reflow Acute Myocardial Infarction Via Sphingosine-1-Phosphate Receptor 1

Abstract

S1P improves cardiac function and myocardial healing post AMI independently of initial infarct size and accomplishes this via the cardiomyocyte S1PR1. Hence, in addition to its beneficial effects on I/R injury, S1PR1 may be a promising target in post-infarction myocardial remodelling as adjunctive therapy to revascularization as well as in patients not eligible for standard interventional procedures.