CD11c+ myeloid cell exosomes reduce intestinal inflammation during colitis

Abstract

MHCII with bound antigen and can travel to lymph nodes and induce tolerance to an orally fed antigen Further, exosomes released from apical versus basolateral surfaces of murine IECs differ in their protein composition, suggesting a specialized function for EVs based on the cell of origin or release mechanism (3). However, the identity, contents, and functions of EVs produced by distinct immune cell types within the GI tract remain undefined.