<i>Sox17</i> Deficiency Promotes Pulmonary Arterial Hypertension via HGF/c-Met Signaling

Abstract

The downregulation of Sox17 levels in pulmonary arterioles increases the susceptibility to PAH, particularly when exposed to hypoxia. Our findings suggest the reactive upregulation of HGF/c-Met signaling as a novel druggable target for PAH treatment.