Predictive value of molecular subtypes and <i>APOBEC3G</i> for adjuvant chemotherapy in urothelial bladder cancer

Abstract

The proposed method robustly replicates the most commonly used transcriptome-based subtype classifications from paraffin-embedded tissue samples. The luminal, but not basal, molecular subtypes had the greatest benefit from adjuvant platinum therapy. We identified and validated APOBEC3G as a novel predictive marker for platinum-treated patients.