CEP-1347 Targets MDM4 Protein Expression to Activate p53 and Inhibit the Growth of Glioma Cells - Concepedia

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CEP-1347 Targets MDM4 Protein Expression to Activate p53 and Inhibit the Growth of Glioma Cells

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2022

Year

Yuta Mitobe, Yurika Nakagawa-Saito, Keita Togashi, Shuhei Suzuki, Asuka Sugai, Kenichiro Matsuda, Yukihiko Sonoda, Chifumi Kitanaka, MASASHI OKADA

Anticancer Research

Abstract

Our findings suggest CEP-1347 is a novel inhibitor of MDM4 protein expression and as such activates p53 to inhibit the growth of cancer cells with wild-type p53, including retinoblastoma and glioblastoma.