Concepedia

Genetic Variants Influencing Circulating Lipid Levels and Risk of Coronary Artery Disease

L. Chen, N. Lim, Xiaotang Yuan, I. Surakka, Wuming Zhang, J. R. Thompson, Kunling Song, P. Elliott, K.-T. Khaw, Sally L. Ricketts,

UNC Libraries · 2020 · 15 citations · 0 references

DOI Full text

Open access

Concepts

MedicineCardiologyGeneticsCardiovascular GeneticsGenetic EpidemiologyMedical GeneticsCardiovascular DiseaseCardiovascular GenomicsCoronary Artery DiseaseGenetic RiskGenetic SusceptibilityIschemic Heart DiseaseAtherosclerosis GeneticsCardiovascular Genetic RiskCoronary Artery Disease GeneticsGenetic Risk VariantsHost Genetic VariantsMetabolic Genetic RiskPharmacogenetics Of Lipid-lowering Therapy

Abstract

Genetic studies might provide new insights into the biological mechanisms underlying lipid metabolism and risk of CAD. We therefore conducted a genome-wide association study to identify novel genetic determinants of LDL-c, HDL-c and triglycerides.