Angiogenic imbalance in pre‐eclampsia and fetal growth restriction: enhanced soluble fms‐like tyrosine kinase‐1 binding or diminished production of placental growth factor?

Abstract

Particularly in pregnancies with early-onset PE and SGA, diminished PlGF production is an important cause of low free PlGF levels. Under such conditions, sFlt-1 lowering is unlikely to restore the angiogenic balance. © 2022 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.