Primary neuroendocrine carcinoma of the breast.

Abstract

Primary neuroendocrine carcinoma of the breast (NECB) is an extremely rare variant of breast cancer having aggressive clinicopathological behaviour and poor prognosis. A 62 years old woman presented with a painless lump in the left breast. Microscopic and immunohistochemical evaluation of the core-tissue biopsy and of the mastectomy specimen revealed moderately-differentiated neuroendocrine carcinoma of the breast. She was labeled as a case of primary neuroendocrine carcinoma of the breast after an infallible exclusion of any concomitant lesion elsewhere in the body. Modified radical mastectomy with level II axillary clearance, chemoradiotherapy and Famoxifen have led to an uneventful 5-year survival till the last follow-up.