Journal of Bone and Joint Surgery · 1976 · 474 citations · 0 references
MedicineOrthopaedic SurgeryOrthopedic SurgeryCartilage RepairOrthopedicsTissue EngineeringArticular Cartilage StructureCartilage BiologyCartilage InjuriesCartilage RegenerationCartilage Repair MaterialsCartilage Tissue EngineeringArticular Cartilage DefectsArticular Cartilage LossCartilage Defect RepairCartilage Repair SurgeryHyaline Cartilage RepairSubchondral Bone PathologySubchondral Bone RegenerationSubchondral Bone Repair
The repair of articular cartilage removed from the femora of adult rabbits at the knee was studied. When multiple perforations were made through the subchondral bone a cartilaginous material, staining heavily with safranin O, first filled the holes. This material resembled hyaline cartilage, and by twelve months there was complete resurfacing of the joint, although the material lost its hyaline appearance after eight months and at one year it resembled dense collagenous tissue.