Protective Effect of Tadenan of Bladder Function Secondary to Partial Outlet Obstruction

Abstract

No AccessJournal of UrologyInvestigative Urology1 Apr 1996Protective Effect of Tadenan of Bladder Function Secondary to Partial Outlet Obstruction Robert M. Levin, J.-P. Riffaud, F. Bellamy, Dorothea Rohrmann, Mohamed Habib, Lev Krasnopolsky, Yang Zhao, and Alan J. Wein Robert M. LevinRobert M. Levin , J.-P. RiffaudJ.-P. Riffaud , F. BellamyF. Bellamy , Dorothea RohrmannDorothea Rohrmann , Mohamed HabibMohamed Habib , Lev KrasnopolskyLev Krasnopolsky , Yang ZhaoYang Zhao , and Alan J. WeinAlan J. Wein View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)66308-0AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Tadenan (DEBAT, Paris, France) is a pharmaceutical agent used in the treatment of benign prostatic hyperplasia (BPH). The specific aim of this study was to determine if pretreatment of rabbits with Tadenan reduced either the hypertrophic response of the bladder to partial outlet obstruction or the accompanying contractile dysfunctions. Materials and Methods: Twenty-five male New Zealand rabbits (3 to 5 kg.) were separated into 5 groups of 5 rabbits each. Each rabbit in groups 1, 2, and 3 received Tadenan orally at 1, 10 and 100 mg./kg./day for 3 weeks. Group 4 received vehicle only (peanut oil); Group 5 were controls. The bladders were evaluated (in vitro studies) after 2 weeks of obstruction. Results: 1) Tadenan did not reduce the effect of partial outlet obstruction on bladder mass. 2) Tadenan pretreatment resulted in a significant protective effect on the contractile responses to field stimulation, bethanechol and KCl. Conclusions: These results clearly demonstrate that Tadenan pretreatment protected the bladder from the contractile dysfunctions induced by partial outlet obstruction. 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Google Scholar Division of Urology, University of Pennsylvania and the Philadelphia Veteran's Administration Medical Center, Philadelphia, Pennsylvania; DEBAT, Groupe FOURNIER, Paris, France; and the Department of Urology, Klinikum der Rheinisch-Westfaelischen Technischen Hochschule, Aachen, Germany© 1996 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byRajasekaran M, Sohn D, Salehi M, Bhargava V, Fritsch H and Mittal R (2012) Role of Puborectalis Muscle in the Genesis of Urethral PressureJournal of Urology, VOL. 188, NO. 4, (1382-1388), Online publication date: 1-Oct-2012.LEVIN R, KAWASHIMA Y, LEGGETT R, WHITBECK C, HORAN P and MIZUTANI K (2018) Effect of Oral Kohki Tea on Bladder Dysfunction Induced by Severe Partial Outlet ObstructionJournal of Urology, VOL. 167, NO. 5, (2260-2266), Online publication date: 1-May-2002.LEVIN R, HASS M, BELLAMY F, HORAN P, WHITBECK K, CHOW P, KUNG L and GOSLING J (2018) Effect of Oral Tadenan Treatment on Rabbit Bladder Structure and Function After Partial Outlet ObstructionJournal of Urology, VOL. 167, NO. 5, (2253-2259), Online publication date: 1-May-2002.PAREKH M, LOBEL R, O’CONNOR L, LEGGETT R and LEVIN R (2018) PROTECTIVE EFFECT OF VITAMIN E ON THE RESPONSE OF THE RABBIT BLADDER TO PARTIAL OUTLET OBSTRUCTIONJournal of Urology, VOL. 166, NO. 1, (341-346), Online publication date: 1-Jul-2001.MACHADO M, YOO J and ATALA A (2018) DEFUNCTIONALIZED BLADDERS: EFFECTS BEFORE AND AFTER REFUNCTIONALIZATION IN AN ANIMAL MODELJournal of Urology, VOL. 164, NO. 3 Part 2, (1002-1007), Online publication date: 1-Sep-2000.GOMES C, DISANTO M, HORAN P, LEVIN R, WEIN A and CHACKO S (2018) IMPROVED CONTRACTILITY OF OBSTRUCTED BLADDERS AFTER TADENAN TREATMENT IS ASSOCIATED WITH REVERSAL OF ALTERED MYOSIN ISOFORM EXPRESSIONJournal of Urology, VOL. 163, NO. 6, (2008-2013), Online publication date: 1-Jun-2000.Yablonsky F, Nicolas V, Riffaud J and Bellamy F (2018) Antiproliferative Effect of Pygeum Africanum Extract on Rat Prostatic FibroblastsJournal of Urology, VOL. 157, NO. 6, (2381-2387), Online publication date: 1-Jun-1997.Levin R, Riffaud J, Bellamy F, Rohrmann D, Krasnopolsky L, Haugaard N, Zhao Y and Wein A (2018) Effects of Tadenan Pretreatment on Bladder Physiology and Biochemistry Following Partial Outlet ObstructionJournal of Urology, VOL. 156, NO. 6, (2084-2088), Online publication date: 1-Dec-1996. Volume 155Issue 4April 1996Page: 1466-1470 Advertisement Copyright & Permissions© 1996 by American Urological Association, Inc.Metrics Author Information Robert M. Levin More articles by this author J.-P. Riffaud More articles by this author F. Bellamy More articles by this author Dorothea Rohrmann More articles by this author Mohamed Habib More articles by this author Lev Krasnopolsky More articles by this author Yang Zhao More articles by this author Alan J. Wein More articles by this author Expand All Advertisement PDF downloadLoading ...