Experimental Infection of African Green Monkeys and Cynomolgus Monkeys With a SIV_AGM Strain Isolated From a Healthy African Green Monkey

Abstract

An infection occurred in all African green monkeys and cynomolgus monkeys experimentally inoculated with SIV AGM [TYO‐1], as demonstrated by the appearance of an antibody to SIV AGM [TYO‐1] and the isolation of the virus. No monkey exhibited overt clinical disorders throughout the experimental period of 42 weeks. Thus, SIV AGM was not pathogenic to its original host or to macaques, This system is proposed as a model for HIV infection manifesting no overt disease.