UNC Libraries · 2020 · 24 citations · 0 references
MedicineBiochemistryInternal MedicineHepatologyMetabolomicsBile Acid MetabolismBiliary Tract DiseaseBiliary Tract DisordersHepatobiliary DiseaseLiver DiseaseMetabolic Liver DiseaseBile Acid-conjugated MetabolitesSerum Bile Acid
The prevalence of non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) is increasing at an alarming rate. The role of bile acids in the development and progression of NAFLD to NASH and cirrhosis is poorly understood. This study aimed to quantify the bile acid metabolome in healthy subjects and patients with non-cirrhotic NASH under fasting conditions and after a standardized meal.