Recombinant Activated Factor VII for Exsanguinating Haemorrhage Post Bilateral Lung Transplantation for Extra-corporeal Lung Support-dependent Respiratory Failure

Abstract

Following three weeks of extracorporeal lung support for acute respiratory distress syndrome, a 15-year-old male underwent bilateral lung transplantation. This procedure was complicated by massive postoperative haemorrhage. The administration of recombinant activated Factor VII was associated with improved haemostasis. However, development of cardiac tamponade soon after injection required emergency exploration and evacuation of a large mediastinal clot.