Concepedia

MERS-CoV nsp1 regulates autophagic flux via mTOR signalling and dysfunctional lysosomes

Yujie Feng, Zhaoyi Pan, Zhihui Wang, Zhengyang Lei, Songge Yang, Huajun Zhao, Xueyao Wang, Yating Yu, Qiuju Han, Jian Zhang

Emerging Microbes & Infections · 2022 · 10 citations · 29 references

DOIFull text

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Concepts

Abstract

. These findings clarify the mechanism by which MERS-CoV nsp1-mediated autophagy regulation, providing new insights for the prevention and treatment of the coronavirus.

References

29

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Geir Bjørkøy, Trond Lamark, Andreas Brech et al. · The Journal of Cell Biology · 2005 · 3.3K citations · Full text

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>

Daniel J. Klionsky, Amal Kamal Abdel‐Aziz, Sara Abdelfatah et al. · Autophagy · 2021 · 2.6K citations · Full text

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Elevated Glucose Levels Favor SARS-CoV-2 Infection and Monocyte Response through a HIF-1α/Glycolysis-Dependent Axis

Ana Campos Codo, Gustavo Gastão Davanzo, Lauar de Brito Monteiro et al. · Cell Metabolism · 2020 · 946 citations · Full text

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Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2

Matthias Thoms, Robert Buschauer, Michael Ameismeier et al. · Science · 2020 · 937 citations · Full text

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β-Coronaviruses Use Lysosomes for Egress Instead of the Biosynthetic Secretory Pathway

Sourish Ghosh, Teegan A. Dellibovi-Ragheb, Adeline Kerviel et al. · Cell · 2020 · 647 citations · Full text

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