Personalized neoantigen vaccine combined with PD-1 blockade increases CD8⁺ tissue-resident memory T-cell infiltration in preclinical hepatocellular carcinoma models

Abstract

This study showed that NeoVAC plus α-PD-1 could induce a strong antitumor response and long-term tumor-specific immune memory in HCC by increasing CD8⁺ T_RMs infiltration, which might serve as a potential immune-therapeutic target for HCC.