Hierarchical microtubes constructed using Fe-doped MoS₂ nanosheets for biosensing applications

Abstract

The structural design of multiple functional components could enhance the synergistic catalytic performance of MoS₂-based composites in enzyme-like catalysis. Herein, one-dimensional (1D) Fe-MoS₂ microtubes were designed to prepare tubular Fe-doped MoS₂ composites with MoO₃ microrods as self-sacrificing precursors. Remarkably, the results indicated that the generated ammonia released from the sulfidation process led to the dissolution of MoO₃ cores and the generation of a tubular structure. The Fe-MoS₂ composites integrated the synergistic effects of Fe-doped MoS₂ nanosheets (NSs) and the 1D tubular structure. Thus, a higher catalytic activity was observed in peroxidase-like catalysis than in other components, such as MoO₃@FeOOH, FeOOH and MoS₂ NSs. The peroxidase-like mechanism originated from the generation of the ˙OH radical. The Fe-MoS₂ microtube-based colorimetric assay was used to detect H₂O₂ with a detection limit (LOD) of 0.51 μM in a linear range from 1.25 to 50 μM. The colorimetric method was simple, selective, and sensitive for glutathione (GSH) detection in the range of 0.25-125 μM with a detection limit (LOD) of 0.12 μM. Thus, we provide a facile synthetic strategy for simultaneously integrating electronic modulation and structural design to develop an efficient MoS₂-based functional catalyst.