Concepedia

Publication | Open Access

METTL1-Mediated m7G tRNA Modification Promotes Lenvatinib Resistance in Hepatocellular Carcinoma

DOIFull Paper Access

174

Citations

32

References

2022

Year

Manling Huang, Jianting Long, Zhijia Yao, Yi Zhao, Yutong Zhao, Junbin Liao, Kai Lei, Han Xiao, Zihao Dai, Sui Peng,
Cancer Research

Abstract

Upregulation of tRNA m7G methyltransferase complex components METTL1 and WDR4 promotes lenvatinib resistance in HCC and confers a sensitivity to METTL1 targeting, providing a promising strategy to override resistance.

References

YearCitations

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