Concepedia

Diffusion mixing with a volatile tertiary amine as a very efficient technique for 1,3-dipolar cycloaddition reactions proceeding <i>via</i> dehydrohalogenation of stable precursors of reactive dipoles

Dmitry E. Shybanov, Maria E. Filkina, Maxim E. Kukushkin, Yuri K. Grishin, Vitaly A. Roznyatovsky, N. V. Zyk

New Journal of Chemistry · 2022 · 20 citations · 38 references

DOI

Concepts

Abstract

Spontaneous diffusion of tertiary amine vapors into a dipolarophile precursor solution is the simplest technique for nitrilylide and nitrilimine generation in 1,3-cycloaddition reactions.

References

38

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[3 + 3]-Cycloaddition of Donor–Acceptor Cyclopropanes with Nitrile Imines Generated in Situ: Access to Tetrahydropyridazines

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Copper-Free “Click” Modification of DNA via Nitrile Oxide−Norbornene 1,3-Dipolar Cycloaddition

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Ângelo Monteiro, Lídia Gonçalves, Maria M. M. Santos · European Journal of Medicinal Chemistry · 2014 · 102 citations

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An Improved Method for Preparation of Nitrile Oxides from Nitroalkanes for In Situ Dipolar Cycloadditions

Yochai Basel · Synthesis · 1997 · 98 citations

, , +10