World Journal of Gastroenterology · 2022 · 15 citations · 31 references
MedicineMolecular BiologyOncologyGastrointestinal OncologyGene ExpressionMolecular OncologyCancer BiomarkersGastric CancerMolecular Tumor ProfilingNoncoding Rna BiologyNoncoding Rna FunctionNoncoding Rna In CancerBiomarkers Of Gastric CancerCancer-related Noncoding Rna FunctionGastric Cancer GeneticsGastric Cancer ScreeningGastric Gastrointestinal Stromal TumorsGastric Ulcer DiseaseLong Non-coding Rna BiomarkersNoncoding Rna Expression Profiling
BACKGROUND: Long noncoding RNA (lncRNA) ZNFX1-AS1 (ZFAS1) is a newly discovered lncRNA, but its diagnostic value in gastric cancer is unclear. AIM: To investigate the potential role of ZFAS1 in gastric cancer and to evaluate the clinical significance of ZFAS1 as a biomarker for gastric cancer screening. METHODS: tumor formation assays. RESULTS: . LIN28 and CAPRIN1 were identified as key downstream mediators of ZFAS1 in gastric cancer cells. CONCLUSION: LncRNA ZFAS1 promoted the invasion and proliferation of gastric cancer cells by modulating LIN28 and CAPRIN1 expression, suggesting that ZFAS1 can be used as a potential diagnostic and prognostic biomarker in gastric cancer.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
PubMed · 1997 · 66.6K citations