The RAND Journal of Economics · 2022 · 17 citations · 35 references
PharmacyPharmaceutical PolicyDrug DiscoveryPharmaceutical TechnologyPharmacoeconomic ModelingNew Drug ApplicationsPharmaceutical EconomicsPharmaceutical MarketingConsumer Demand TheoryNoveltyPharmaceutical Innovation Strategy
Abstract Prior literature shows that stronger consumer demand leads to increased pharmaceutical R&D. However, how strong these “demand‐pull” effects are for more scientifically novel drug innovation remains unknown. We address this question using comprehensive clinical trial data that include precise characterizations of the scientific approaches used in tested molecules. We characterize scientific novelty as the number of times each approach has been used in the past. Exploiting exogenous demand variation introduced by the introduction of Medicare Part D, we find strong evidence that demand‐pull effects are markedly skewed in favor of non‐novel or “follow‐on” drug R&D.
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Recombinant Uncertainty in Technological Search
Lee Fleming · Management Science · 2001 · 2.8K citations
Management, Innovation Management, Technology Management +17
Clinical development success rates for investigational drugs
Michael Hay, David W. Thomas, John L. Craighead et al. · Nature Biotechnology · 2014 · 2.5K citations
Estimation of clinical trial success rates and related parameters
Chi Heem Wong, Kien Wei Siah, Andrew W. Lo · Biostatistics · 2017 · 1.5K citations · Full text
Medicine, Biostatistics, Oncology +10