Photoredox-Catalyzed C–H Trideuteromethylation of Quinoxalin-2(1<i>H</i>)-ones with CDCl₃ as the “CD₃” source

Abstract

Herein, readily available and inexpensive CDCl₃ was first identified as a new trideuteromethylation reagent under photoredox-catalyzed conditions. Thus, a facile photocatalytic protocol for the C-H trideuteromethylation of quinoxalin-2(1<i>H</i>)-one was achieved. This operationally straightforward transformation displays a broad scope and provides a new route to introduce the trideuteromethyl group (CD₃) with excellent levels of deuterium content.