Differences in <scp>Sex‐Specific</scp> Frequency of Glucocerebrosidase Variant Carriers and Familial Parkinsonism

Abstract

Our study demonstrates that the male-sex predominance present in GBA PD overall was not consistent across GBA variant severities, and a female-sex predominance was present among severe GBA variant carriers. Therefore, research and trial designs for PD should consider sex-specific differences, including across GBA variant severities. © 2022 International Parkinson and Movement Disorder Society.