Treatment patterns and outcomes in metastatic synovial sarcoma: a real-world study in the US oncology network

Abstract

<b>Aim:</b> To examine and understand patient characteristics, treatment patterns and outcomes for patients with metastatic synovial sarcoma (mSS) treated in a US community setting. <b>Materials & methods:</b> Retrospective observational study in adults with mSS in The US Oncology Network (diagnosed January 2012-December 2018). <b>Results:</b> Of 202 patients diagnosed with synovial sarcoma (SS), 71 had mSS. Of 39 patients with mSS who received first-line (1L) systemic treatment, 25 and 16 continued to 2L and 3L+ treatment, respectively. With each subsequent treatment line, time-to-treatment-discontinuation (1L-3L: 3.9-2.7 months) and time-to-next-treatment (1L-3L: 9.3-4.6 months) decreased. At 1L, median overall survival was 24.5 months. <b>Conclusion:</b> This study highlights the ongoing need for effective therapies for mSS.