Concepedia

<i>Fusobacterium nucleatum</i> Extracellular Vesicles Promote Experimental Colitis by Modulating Autophagy via the miR-574-5p/CARD3 Axis

Shuchun Wei, Jixiang Zhang, Xiaohan Wu, Meilin Chen, Hancheng Huang, Suqi Zeng, Zixuan Xiang, Xiangyun Li, Weiguo Dong

Inflammatory Bowel Diseases · 2022 · 46 citations · 35 references

DOI

Abstract

Here, we describe a new mechanism by which Fn-EVs mediate experimental colitis severity through miR-574-5p/CARD3-dependent autophagy activation, providing a novel target for UC monitoring and targeted therapy.

References

35

The global, regional, and national burden of inflammatory bowel disease in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

Sudabeh Alatab, Sadaf G Sepanlou, Kevin S Ikuta et al. · ˜The œLancet. Gastroenterology & hepatology · 2019 · 2.2K citations · Full text

Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy

Ta-Chung Yu, Fangfang Guo, Yanan Yu et al. · Cell · 2017 · 2.1K citations · Full text

, , +6

Fusobacterium nucleatum Increases Proliferation of Colorectal Cancer Cells and Tumor Development in Mice by Activating Toll-Like Receptor 4 Signaling to Nuclear Factor−κB, and Up-regulating Expression of MicroRNA-21

Yongzhi Yang, Wenhao Weng, Junjie Peng et al. · Gastroenterology · 2016 · 935 citations · Full text

, , +13

Gram‐positive bacteria produce membrane vesicles: Proteomics‐based characterization of <i>Staphylococcus aureus</i> ‐derived membrane vesicles

Eun‐Young Lee, Do‐Young Choi, Dae‐Kyum Kim et al. · PROTEOMICS · 2009 · 653 citations

Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

Hiutung Chu, Arya Khosravi, Indah P. Kusumawardhani et al. · Science · 2016 · 613 citations · Full text