Targeting DNA Repair with Combined Inhibition of NHEJ and MMEJ Induces Synthetic Lethality in <i>TP53</i> -Mutant Cancers - Concepedia

Concepedia

Publication | Open Access

Targeting DNA Repair with Combined Inhibition of NHEJ and MMEJ Induces Synthetic Lethality in <i>TP53</i> -Mutant Cancers

DOI Full Paper Access

58

Citations

50

References

2022

Year

Jeffrey Patterson-Fortin, Arindam Bose, Wei-Chih Tsai, Carter Grochala, Huy Nguyen, Jia Zhou, Kalindi Parmar, Jean‐Bernard Lazaro, Joyce F. Liu, Kelsey McQueen,

Cancer Research

Abstract

Combined inhibition of NHEJ and MMEJ using two nontoxic, targeted DNA repair inhibitors can effectively induce toxic DNA damage to treat TP53-deficient cancers.

References

	Year	Citations

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