Scientific Data · 2022 · 20 citations · 21 references
ComputingBiomedical InformaticsClinical Data ManagementDistributed SystemsKnowledge StorageData LineageData PipelinesData ProvenanceDistributed ComputingDistributed StorageResearch Data ManagementData Provenance ModelingDistributed ProvenanceImage ProvenanceProvenance CaptureProvenance Data ModelsProvenance ModelsProvenance Representation
Provenance is information describing the lineage of an object, such as a dataset or biological material. Since these objects can be passed between organizations, each organization can document only parts of the objects life cycle. As a result, interconnection of distributed provenance parts forms distributed provenance chains. Dependant on the actual provenance content, complete provenance chains can provide traceability and contribute to reproducibility and FAIRness of research objects. In this paper, we define a lightweight provenance model based on W3C PROV that enables generation of distributed provenance chains in complex, multi-organizational environments. The application of the model is demonstrated with a use case spanning several steps of a real-world research pipeline - starting with the acquisition of a specimen, its processing and storage, histological examination, and the generation/collection of associated data (images, annotations, clinical data), ending with training an AI model for the detection of tumor in the images. The proposed model has become an open conceptual foundation of the currently developed ISO 23494 standard on provenance for biotechnology domain.
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Raise standards for preclinical cancer research
C. Glenn Begley, Lee M. Ellis · Nature · 2012 · 2.9K citations · Full text
Medicine, Cancer Biology, Oncology +12
The protection of information in computer systems
Jerome H. Saltzer, Michael Schroeder · Proceedings of the IEEE · 1975 · 1.9K citations
A call for transparent reporting to optimize the predictive value of preclinical research
Story C. Landis, Susan Amara, Khusru Asadullah et al. · Nature · 2012 · 1.2K citations · Full text