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A Novel Oral GyrB/ParE Dual Binding Inhibitor Effective against Multidrug-Resistant <i>Neisseria gonorrhoeae</i> and Other High-Threat Pathogens

Steven Park, Riccardo Russo, Landon Westfall, Riju Shrestha, Matthew Zimmerman, Véronique Dartois, Natalia Kurepina, Barry N. Kreiswirth, Eric Singleton, Shaogang Li,

Antimicrobial Agents and Chemotherapy · 2022 · 10 citations · 34 references

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Abstract

activity against high-threat Gram-positive organisms, and JSF-2659 was shown in a deep tissue model of vancomycin-resistant Staphylococcus aureus (VRSA) and a model of Clostridioides difficile-induced colitis to be highly efficacious and protective. JSF-2659 is a novel preclinical drug candidate against high-threat multidrug resistant organisms with low potential to develop new resistance.

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