Fatal Fungicide-Associated Triazole-Resistant <i>Aspergillus fumigatus</i> Infection, Pennsylvania, USA

Abstract

We report a fatal infection in a 65-year-old immunocompromised male patient caused by pan-triazole-resistant Aspergillus fumigatus containing a TR₃₄/L98H genetic mutation linked to agricultural fungicide use. Clinical and environmental surveillance of triazole-resistant A. fumigatus is needed in the United States to prevent spread and guide healthcare and agricultural practices.