TNF-α inhibitor ameliorates immune-related arthritis and pneumonitis in humanized mice

Abstract

We successfully established a humanized mouse model of ICI-related severe arthritis and pneumonitis with a higher frequency of TNF-α⁺ T cells, which were significantly mitigated by anti-TNF-α treatment. Conceptually, ICI treatment can induce multiple autoimmune-like diseases in autoimmune-prone individuals and TNF-α⁺ T cells may be therapeutic targets for intervention of immune-related arthritis and pneumonitis.