JCO Precision Oncology · 2022 · 14 citations · 29 references
MedicineOncologyPathologyCancer ImmunologyNeoplasiaTumor ImmunologyCancer ImmunotherapyImmune Checkpoint InhibitorsImmuno-oncology BiomarkersTumor AntigensTumor ImmunopathologyTumor-associated AntigensCd8+ Tumor-infiltrating LymphocytesImmunofluorescence AssaysImmunofluorescence FindingsLeiomyosarcoma TherapyMicrosatellite Instability AnalysisPembrolizumab TherapyTumor Mutational BurdenTumor Mutational Burden Assessment
FIG 5. Multiplex immunohistochemistry/immunofluorescence applied to a section of the tumor showed various tumor-infiltrating immune cells: (A) CD3, (B) CD8, (C) CD68, (D) FOXP3, and (E) PD-L1. PD-L1-positive cells (19.7%) were also present. PD-L1, programmed death ligand-1.
29
PD-1 Blockade in Tumors with Mismatch-Repair Deficiency
Dung T. Le, Jennifer N. Uram, Hao Wang et al. · New England Journal of Medicine · 2015 · 9.4K citations · Full text
Life Sciences, Immunology, Oncology +17
Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade
Dung T. Le, Jennifer N. Durham, Kellie N. Smith et al. · Science · 2017 · 6.6K citations
Life Sciences, Immunology, Oncology +17
Aurélien Marabelle, Dung T. Le, Paolo A. Ascierto et al. · Journal of Clinical Oncology · 2019 · 3K citations · Full text
Life Sciences, Immunology, Oncology +17
Aurélien Marabelle, Marwan Fakih, Juanita Lopez et al. · The Lancet Oncology · 2020 · 2.5K citations · Full text
Medicine, Oncology, Pharmacotherapy +17
Landscape of Microsatellite Instability Across 39 Cancer Types
Russell Bonneville, Melanie A. Krook, Esko A. Kautto et al. · JCO Precision Oncology · 2017 · 1.5K citations
Life Sciences, Genetics, Oncology +17