GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis

Abstract

Inflammatory-proliferative fibroblasts play a key role in the early pathological changes that occur in silicosis, and during this process, GREM1 is the driving factor that targets PPP2R3A and initiates the inflammatory response, which is followed by irreversible fibrosis induced by SiO₂. The GREM1/PPP2R3A pathway may be a potential target in the early treatment of silicosis.